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Related Experiment Video

Updated: Apr 20, 2026

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Published on: January 19, 2024

Low-grade glioma.

Priya Kumthekar¹, Jeffrey Raizer, Simran Singh

¹Department of Neurology, Northwestern University, 710 North Lake Shore Drive, Abbott Hall, 11th Floor, Chicago, IL, 60611, USA, pkumthek@nmff.org.

Cancer Treatment and Research

|December 4, 2014

Summary

This summary is machine-generated.

Early surgery and radiation improve survival for low-grade gliomas. Molecular markers like IDH1 mutations and 1p/19q codeletion influence treatment response and prognosis in these slow-growing brain tumors.

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A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas

Published on: May 9, 2025

Area of Science:

Neuro-oncology
Neurosurgery
Radiation Oncology

Background:

Low-grade gliomas (LGGs) are primary brain tumors with a median survival of 4.7-9.8 years.
They represent 10-20% of all primary brain tumors.
Treatment aims to maximize survival and quality of life (QOL).

Purpose of the Study:

To review current treatment strategies for low-grade gliomas.
To highlight the role of early surgical resection and adjuvant therapies.
To discuss the impact of molecular markers on treatment outcomes.

Main Methods:

Review of recent clinical data and trials on low-grade glioma management.
Analysis of treatment outcomes based on extent of resection (EOR), radiation doses, and chemotherapy regimens.
Correlation of molecular markers (1p/19q codeletion, IDH1 mutation) with treatment response.

Main Results:

Early surgical resection and achieving gross total resection (GTR) are associated with delayed recurrence and improved survival.
Adjuvant radiation therapy (45-50.4 Gy) and chemotherapy (temozolomide preferred) benefit high-risk patients.
1p/19q codeletion and IDH1 mutations are significant predictors of treatment response and survival.

Conclusions:

Optimizing treatment for low-grade gliomas involves a multimodal approach.
Extent of resection, judicious use of radiation, and consideration of molecular markers are crucial.
Temozolomide is a well-tolerated and effective chemotherapy option.