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Quantifying recording quality in in vivo striatal recordings
Danielle M Friend1, Caleb Kemere2, Alexxai V Kravitz1,3
1National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland.
Current Protocols in Neuroscience
|January 7, 2015
Summary
This study details in vivo electrophysiology for recording striatal activity during behavior. It covers equipment, setup, and data analysis for studying movement, decision-making, and reward learning.
Area of Science:
- Neuroscience
- Electrophysiology
- Behavioral Neuroscience
Background:
- The striatum is crucial for motor control, decision-making, motivation, and reward learning.
- In vivo recording enables direct observation of neural activity in awake, behaving animals.
Purpose of the Study:
- To provide a comprehensive protocol for in vivo electrophysiology in the rodent striatum.
- To outline essential equipment, experimental setup, and data processing techniques.
Main Methods:
- Detailed description of necessary equipment for in vivo electrophysiology.
- Step-by-step guide to experimental setup and recording procedures.
- Methods for data processing and quality control of electrophysiological recordings.
Main Results:
- Successful implementation of in vivo electrophysiology for striatal recordings.
- Quantification of recording quality metrics.
- Demonstration of the protocol's applicability to studying striatal functions.
Conclusions:
- This protocol facilitates the investigation of striatal circuits during complex behaviors.
- The described methods are adaptable for electrophysiological recordings in other brain regions.
