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Updated: Apr 18, 2026

Establishing a Silicosis Rat Model via Exposure of Whole-Body to Respirable Silica
Published on: October 28, 2022
[Working as a sandblaster can cause silicosis]
Jacob Schelde1, Georg Authried, Helle Dall Madsen
1Arbejds- og Miljømedicinsk Klinik, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C. oj.schelde@gmail.com.
Abstract:
Silicosis is a common occupational disease worldwide. It is caused by the inhalation of crystalline silicon dioxide, i.e. silica. Quartz is a common form of silica and occurs in sandstone and granite. Occupational exposure can occur e.g. in mining, quarrying and sandblasting. The inhaled silica triggers an inflammatory response when phagocytosed which eventually causes fibrosis. We present a 45-year-old male Danish sandblaster who developed silicosis, and due to rapid decline in lung function received a lung transplant with an excellent result.
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