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Related Concept Videos

Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
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Pancreas01:19

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The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
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Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
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Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
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Erratum.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
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OPTN/SRTR 2020 Annual Data Report: Living Donor Collective

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OPTN/SRTR 2013 Annual Data Report: pancreas.

R Kandaswamy1, M A Skeans, S K Gustafson

  • 1Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN; Department of Surgery, University of Minnesota, Minneapolis, MN.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|January 29, 2015
PubMed
Summary

Pancreas transplants declined, but outcomes improved. New allocation systems aim for equitable access and reduced wait times, especially for simultaneous pancreas-kidney candidates. Graft failure definitions are being refined for better outcome analysis.

Keywords:
Pancreas after kidney transplantpancreas allocation policypancreas transplant alonesimultaneous pancreas-kidney transplant

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Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Organ Transplantation

Background:

  • Pancreas listings and transplants have decreased over the last decade, with a notable decline in pancreas-after-kidney transplants.
  • Despite decreasing numbers, pancreas transplant outcomes, both short-term and long-term, have shown improvement across all patient groups.
  • Current challenges include interpreting outcomes due to a lack of uniform graft failure definitions and high risks of technical failures, rejection, and surgical complications.

Purpose of the Study:

  • To summarize trends in pancreas transplantation, including changes in organ availability and patient outcomes.
  • To outline upcoming changes to the national pancreas allocation system designed to improve efficiency and equity.
  • To highlight ongoing challenges and the critical need for continued innovation in pancreas transplantation.

Main Methods:

  • Analysis of national pancreas transplant data over the past decade.
  • Review of changes implemented in the pancreas allocation system (effective late 2014).
  • Discussion of efforts to establish a uniform definition for pancreas graft failure.

Main Results:

  • A decrease in overall pancreas transplants, particularly pancreas-after-kidney transplants, was observed.
  • Significant improvements in short-term and long-term pancreas transplant outcomes have been documented.
  • New allocation policies will create a single national list, prioritizing simultaneous pancreas-kidney candidates to reduce wait times and mortality.

Conclusions:

  • The new pancreas allocation system is expected to standardize organ distribution nationwide and decrease waitlist mortality for high-risk candidates.
  • Establishing a uniform definition for graft failure is crucial for accurate future outcomes analysis and research.
  • Continued advancements in pancreas transplantation are essential, especially with emerging alternatives like islet transplantation and artificial pancreas technology.