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Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
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Cell signalling during blastocyst morphogenesis.

Judith J Eckert1, Miguel A Velazquez, Tom P Fleming

  • 1Human Development and Health, Faculty of Medicine, University of Southampton, SO16 6YD, Southampton, UK.

Advances in Experimental Medicine and Biology
|May 10, 2015
PubMed
Summary
This summary is machine-generated.

Parental gametes influence early embryonic gene expression and blastocyst development. Signaling pathways guide cell differentiation and lineage allocation, promoting adaptive plasticity for survival.

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Area of Science:

  • Developmental biology
  • Embryology
  • Cell signaling

Background:

  • Early embryonic development, including blastocyst morphogenesis, is influenced by factors present before fertilization.
  • Parental gametes store information that shapes embryonic gene expression post-fertilization.
  • Complex signaling networks regulate key developmental stages like cleavage, compaction, and cavitation.

Purpose of the Study:

  • To elucidate the intricate interplay between intrinsic and extrinsic signals governing blastocyst morphogenesis.
  • To highlight the role of signaling mechanisms in ensuring developmental progression and cell fate determination.
  • To emphasize the developmental plasticity that allows embryos to adapt to environmental conditions.

Main Methods:

  • This chapter focuses on studies in the mouse model.
  • Analysis of intrinsic and extrinsic signaling pathways.
  • Observational studies on cleavage, compaction, and cavitation stages.

Main Results:

  • Signaling events are crucial for cell differentiation and lineage allocation to the inner cell mass and trophectoderm.
  • Developmental plasticity enables adaptive responses for embryo survival.
  • Cellular functions like metabolism and gene expression exhibit plasticity with long-term consequences.

Conclusions:

  • Understanding blastocyst morphogenesis requires examining both internal and external signaling influences.
  • Mouse models provide key insights, with future research aiming for translational significance in human and animal embryology.
  • Embryonic development exhibits plasticity, impacting cellular functions and potentially adult phenotypes.