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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.3K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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What is the Immune System?01:38

What is the Immune System?

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Overview
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Related Experiment Video

Updated: Apr 11, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
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Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

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[Myelodysplastic syndromes and autoimmunity].

G Stalder, L Alberio, C Ribi

    Revue Medicale Suisse
    |June 5, 2015
    PubMed
    Summary

    Myelodysplastic syndromes (MDS) are linked to autoimmune disorders, with patients in either group having an increased risk of developing the other. This review explores the connection and provides guidance for clinical practice.

    Area of Science:

    • Hematology
    • Immunology
    • Oncology

    Context:

    • Myelodysplastic syndromes (MDS) involve ineffective blood cell production from clonal stem cell disorders.
    • MDS patients exhibit a higher incidence of systemic inflammatory and autoimmune diseases.
    • Autoimmune disease patients face an elevated risk of developing MDS.

    Purpose:

    • To review the association between myelodysplasia and autoimmunity.
    • To provide clinical guidance on identifying MDS in autoimmune patients.
    • To list autoimmune conditions that can complicate MDS progression.

    Summary:

    • MDS, a group of clonal hematopoietic stem cell disorders, leads to inefficient hematopoiesis and peripheral cytopenias.
    • A significant link exists between MDS and autoimmune disorders, supported by cohort studies and case reports.

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    Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
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  • The relationship is bidirectional: MDS patients are prone to autoimmune diseases, and autoimmune patients have a higher risk of MDS.

    • Impact:

    • Enhances understanding of the complex interplay between MDS and autoimmunity.
    • Offers practical insights for clinicians managing patients with either condition.
    • Aids in the early detection and management of MDS in the context of autoimmune diseases.