Related Experiment Video
Updated: Apr 10, 2026
08:42
A Reproducible Cartilage Impact Model to Generate Post-Traumatic Osteoarthritis in the Rabbit
Published on: November 21, 2023
2.0K
PRP and articular cartilage: a clinical update
Antonio Marmotti1, Roberto Rossi2, Filippo Castoldi2
1Department of Orthopaedics and Traumatology, University of Torino, 10100 Torino, Italy ; Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy.
Biomed Research International
|June 16, 2015
Summary
Platelet-rich plasma (PRP) shows promise for treating cartilage lesions and osteoarthritis, both surgically and via injection. While its biological role is fascinating, clinical use remains exploratory.
Area of Science:
- Orthopedics
- Regenerative Medicine
- Biologics
Background:
- Platelet-rich plasma (PRP) is gaining attention for its therapeutic potential in cartilage repair and osteoarthritis.
- Recent studies suggest PRP can be used as an adjunct to surgery for cartilage defects or as an intra-articular injection for osteoarthritis.
Purpose of the Study:
- To review the trophic and anti-inflammatory properties of PRP.
- To summarize current literature on PRP applications in cartilage surgery and osteoarthritis treatment.
Main Methods:
- Literature review of case series and comparative studies.
- Analysis of PRP products and their clinical applications.
Main Results:
- PRP exhibits significant biological activity, including trophic and anti-inflammatory effects.
- Evidence supports PRP's use in both surgical and conservative management of cartilage issues.
Conclusions:
- PRP demonstrates a compelling biological role in cartilage regeneration and osteoarthritis management.
- Further research is needed to clarify optimal protocols and solidify clinical applications, as current use is considered exploratory.
Related Concept Videos
01:27Growth of Cartilage and Bone Tissue
4.9K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
4.9K
01:16Structural Joints: Synovial Joints
9.8K
Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
9.8K
01:23Knee Joint
3.7K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
3.7K