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Chordomas: A Review.

Bernard George1, Damien Bresson1, Philippe Herman2

  • 1Department of Neurosurgery, Hôpital LARIBOISIERE, Assistance Publique - Hôpitaux de Paris, Université Paris Diderot, 2 rue Ambroise Paré, Paris 75475, France.

Neurosurgery Clinics of North America
|July 5, 2015
PubMed
Summary
This summary is machine-generated.

Chordomas (CHs) are challenging bone tumors. Optimal treatment requires radical resection and understanding molecular drivers for targeted therapies.

Keywords:
ChordomasEndonasal approachProton beam therapy

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiation Oncology

Background:

  • Chordomas (CHs) are rare bone tumors with benign histology but aggressive behavior.
  • CHs present significant treatment challenges, with ongoing questions regarding optimal management strategies.
  • Invasive and metastatic potential complicates the prognosis and treatment of chordomas.

Purpose of the Study:

  • To review current treatment strategies for chordomas.
  • To highlight the need for a better understanding of chordoma oncogenesis.
  • To explore future directions in chordoma therapy, including targeted chemotherapies.

Main Methods:

  • Review of existing literature on chordoma treatment.
  • Analysis of current clinical practices in chordoma management.
  • Discussion of molecular biology and oncogenesis research in chordomas.

Main Results:

  • Radical resection is the recommended primary treatment for all chordomas.
  • Proton therapy is often used post-operatively, though its efficacy in incomplete resections is not fully established.
  • Current treatment paradigms highlight the need for improved therapeutic approaches.

Conclusions:

  • Future chordoma treatment hinges on understanding molecular biology and oncogenesis.
  • Development of targeted chemotherapies is crucial for improving outcomes.
  • Multidisciplinary approaches integrating surgery, radiation, and novel therapies are essential.