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Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Quantifying temperature-dependent T1 changes in cortical bone using ultrashort echo-time MRI.

Misung Han¹, Viola Rieke¹, Serena J Scott²

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.

Magnetic Resonance in Medicine

|September 22, 2015

Summary

This summary is machine-generated.

This study shows ultrashort echo-time MRI can measure temperature changes in cortical bone. T1 relaxation time increases linearly with temperature, proving its feasibility for thermal monitoring.

Keywords:

MR temperature mapping T1 mapping UTE imaging cortical bone

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Area of Science:

Biomedical Engineering
Magnetic Resonance Imaging
Bone Tissue Research

Background:

Cortical bone's thermal properties are crucial for medical applications.
Accurate temperature monitoring in bone is challenging with conventional MRI.

Purpose of the Study:

To assess the feasibility of ultrashort echo-time (USE) MRI for quantifying T1 changes in cortical bone due to heating.
To establish a method for non-invasive thermal monitoring in bone tissue.

Main Methods:

Utilized variable flip-angle T1 mapping with 3D ultrashort echo-time imaging.
Performed calibration experiments on ex vivo bovine femur bone to correlate T1 with temperature.
Conducted ultrasound heating experiments on bone specimens to quantify heat-induced T1 changes.

Main Results:

Demonstrated a temperature-dependent increase in T1 relaxation time in cortical bone.
Observed a linear relationship between temperature and T1 (0.67-0.84 ms/°C) from 25-70°C.
Ultrasound heating resulted in T1 changes consistent with calibration data.

Conclusions:

Successfully demonstrated the temperature dependence of T1 in ex vivo cortical bone.
Validated the variable flip-angle ultrashort echo-time T1 mapping method for thermal sensing in bone.