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Conjunctival TGF-B Level in Primary Augmented Trabeculectomy.
Guan Fook Ng1, Ishak Siti Raihan1, Yaakub Azhany1
1Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kota Bharu, Kelantan, Malaysia.
The Open Ophthalmology Journal
|September 25, 2015
Summary
Glaucoma patients have higher conjunctival transforming growth factor beta (TGF-β) levels. Reduced TGF-β after surgery may predict trabeculectomy success.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Cell Biology
Background:
- Glaucoma is a leading cause of irreversible blindness.
- Transforming growth factor beta (TGF-β) plays a role in ocular fibrotic processes.
- Augmented trabeculectomy is a surgical option for refractory glaucoma.
Purpose of the Study:
- To compare conjunctival TGF-β levels in glaucoma patients versus controls.
- To assess changes in conjunctival TGF-β levels before and after augmented trabeculectomy.
- To explore TGF-β as a potential biomarker for surgical success.
Main Methods:
- Conjunctival impression cytology was performed on 18 glaucoma patients and 18 controls.
- Flow cytometry analyzed TGF-β levels using anti-TGF-β antibody.
- Glaucoma patients were assessed pre- and post-surgery (3 months).
Main Results:
- Glaucoma patients exhibited significantly higher conjunctival TGF-β levels (35.21% ± 14.12%) compared to controls (14.96% ± 6.34%) (p=0.001).
- Augmented trabeculectomy led to a significant reduction in TGF-β levels (23.0% ± 13.8%) (p<0.001).
- A greater TGF-β reduction correlated with successful surgical outcomes (p=0.029).
Conclusions:
- Conjunctival TGF-β reduction post-trabeculectomy may indicate short-term surgical success.
- TGF-β could serve as a predictive marker for trabeculectomy outcomes.
- Limitations include sample size and potential confounding factors.
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