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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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The two main cell...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Whole Body Regeneration01:33

Whole Body Regeneration

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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

5.8K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Related Experiment Video

Updated: Apr 1, 2026

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
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Regenerative Medicine: Solution in Sight.

Qingjie Wang1, Jeffrey H Stern2, Sally Temple3

  • 1Neural Stem Cell Institute, Regenerative Research Foundation, 12144, Rensselaer, NY, USA. qingjiewang@neuralsci.org.

Advances in Experimental Medicine and Biology
|October 3, 2015
PubMed
Summary
This summary is machine-generated.

Stem cell technology offers hope for vision loss by generating retinal cells. This research reviews advances in stem cell therapies for retinal diseases like Age-related macular degeneration (AMD) and retinitis pigmentosa (RP).

Keywords:
Direct cellular reprogrammingDisease modelingProgenitorRPERetinaStem cellshESCiPSC

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • The human retina exhibits limited regenerative capacity, leading to permanent vision loss from diseases like Age-related macular degeneration (AMD) and retinitis pigmentosa (RP).
  • Current therapeutic strategies for retinal degenerative diseases are insufficient to restore lost vision due to the inability to replace damaged retinal cells.

Purpose of the Study:

  • To review recent advancements in stem cell research for generating retinal pigment epithelium (RPE) and retinal cells.
  • To explore the potential of stem cell-derived cells for cell replacement therapies and disease modeling in retinal disorders.

Main Methods:

  • Review of current literature on stem cell differentiation protocols for RPE and retinal neurons.
  • Analysis of studies utilizing stem cell-derived cells for disease modeling and therapeutic development.

Main Results:

  • Stem cell technologies have enabled the abundant production of neural cells, including RPE and retinal cell types.
  • Significant progress has been made in generating patient-specific cells for disease-in-a-dish models to understand disease mechanisms.

Conclusions:

  • Stem cell-based approaches hold significant promise for treating retinal degenerative diseases.
  • Future research should focus on optimizing cell generation, transplantation, and disease modeling for clinical translation.