Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome reorganization and its functional impact during breast cancer progression.

eLife·2026
Same author

Connecting multiway enhancer-promoter interactions to changes in gene expression in cancer.

bioRxiv : the preprint server for biology·2026
Same author

Orderly mitosis shapes interphase genome architecture.

eLife·2026
Same author

Ubiquitin-dependent recruitment of SLFN11 to chromatin is regulated by deubiquitinase (DUB) and RNF168.

Research square·2026
Same author

TAD boundaries and gene activity are uncoupled.

eLife·2026
Same author

Ubiquitin-dependent recruitment of SLFN11 to chromatin is regulated by deubiquitinase (DUB) and RNF168.

bioRxiv : the preprint server for biology·2026
Same journal

Functional and Mechanistic Interplay of Host and Viral Alternative Splicing Regulation during Influenza Infection.

Cold Spring Harbor symposia on quantitative biology·2020
Same journal

Myriad RNAs and RNA-Binding Proteins Control Cell Functions, Explain Diseases, and Guide New Therapies.

Cold Spring Harbor symposia on quantitative biology·2020
Same journal

Small RNA Function in Plants: From Chromatin to the Next Generation.

Cold Spring Harbor symposia on quantitative biology·2020
Same journal

U1 snRNP Telescripting Roles in Transcription and Its Mechanism.

Cold Spring Harbor symposia on quantitative biology·2020
Same journal

The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops.

Cold Spring Harbor symposia on quantitative biology·2020
Same journal

Biophysical Properties of HP1-Mediated Heterochromatin.

Cold Spring Harbor symposia on quantitative biology·2020
See all related articles

Related Experiment Video

Updated: Mar 31, 2026

High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization
08:48

High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization

Published on: June 28, 2012

12.2K

HIPMap: A High-Throughput Imaging Method for Mapping Spatial Gene Positions.

Sigal Shachar1, Gianluca Pegoraro1, Tom Misteli1

  • 1National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

Cold Spring Harbor Symposia on Quantitative Biology
|October 17, 2015
PubMed
Summary
This summary is machine-generated.

HIPMap is a new pipeline for mapping gene locations in the 3D nucleus. This tool helps understand how gene positioning affects DNA functions and nuclear organization.

More Related Videos

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.5K
A High Throughput in situ Hybridization Method to Characterize mRNA Expression Patterns in the Fetal Mouse Lower Urogenital Tract
10:24

A High Throughput in situ Hybridization Method to Characterize mRNA Expression Patterns in the Fetal Mouse Lower Urogenital Tract

Published on: August 19, 2011

13.6K

Related Experiment Videos

Last Updated: Mar 31, 2026

High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization
08:48

High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization

Published on: June 28, 2012

12.2K
Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.5K
A High Throughput in situ Hybridization Method to Characterize mRNA Expression Patterns in the Fetal Mouse Lower Urogenital Tract
10:24

A High Throughput in situ Hybridization Method to Characterize mRNA Expression Patterns in the Fetal Mouse Lower Urogenital Tract

Published on: August 19, 2011

13.6K

Area of Science:

  • Genomics
  • Molecular Biology
  • Cell Biology

Background:

  • Gene location within the nucleus influences DNA transcription, replication, and repair.
  • Understanding the cellular factors that dictate gene positioning is a key challenge in nuclear architecture research.

Purpose of the Study:

  • To introduce HIPMap, a high-throughput imaging and analysis pipeline.
  • To enable the precise mapping of endogenous gene loci within the 3D nuclear space.

Main Methods:

  • HIPMap utilizes high-throughput imaging techniques.
  • The pipeline incorporates advanced analysis for 3D spatial mapping of gene loci.

Main Results:

  • HIPMap provides a versatile platform for various applications.
  • The pipeline facilitates screening, translocation mapping, and validation of other genomic data.

Conclusions:

  • HIPMap is a valuable tool for studying nuclear architecture.
  • It allows for in-depth investigation of gene function, DNA-protein interactions, and gene expression in relation to nuclear positioning.