Related Experiment Video
Updated: Mar 31, 2026
09:44
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
10.7K
Single-Fraction Radiotherapy for CD30(+) Lymphoproliferative Disorders
Michelle S Gentile1, Maria Estela Martinez-Escala2, Tarita O Thomas3
1Department of Radiation Oncology, Northwestern University, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA.
Biomed Research International
|October 28, 2015
Summary
Palliative radiation therapy effectively treats CD30(+) lymphoproliferative disorder lesions that have not responded to prior treatments. A single radiation dose is as effective as multiple doses, offering greater convenience for patients with cutaneous T-cell lymphoma.
Area of Science:
- Dermatology
- Radiation Oncology
- Hematology
Background:
- CD30(+) lymphoproliferative disorder is a rare cutaneous T-cell lymphoma variant.
- Complete response to first-line treatments for this condition is uncommon.
- This study examines palliative radiation therapy for refractory or recurrent lesions.
Purpose of the Study:
- To evaluate the efficacy of palliative radiation therapy in treating CD30(+) lymphoproliferative disorder.
- To compare single-fraction versus multifractionated radiation courses.
- To assess response rates and toxicity in radiation-naïve patients.
Main Methods:
- Retrospective review of 6 patients (12 lesions) with symptomatic CD30(+) lymphoproliferative disorder.
- Exclusion of patients with other cutaneous T-cell lymphoma variants or prior radiation.
- Treatment involved single or multifractionated radiation doses using electrons and bolus.
Main Results:
- All treated lesions achieved a 100% complete response rate.
- Acute side effects were limited to grade 1-2 dermatitis.
- Median follow-up was 113 months, demonstrating sustained response.
- Single-fraction radiation (750-800 cGy) showed comparable efficacy to multifractionated courses (4000-4500 cGy).
Conclusions:
- Palliative radiation therapy is highly effective for radiation-naïve CD30(+) lymphoproliferative disorder.
- A single radiation fraction is a convenient and effective treatment option.
- This approach offers excellent response rates with manageable toxicity.
