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Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

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Routes of Drug Administration: Parenteral01:25

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Updated: Mar 30, 2026

Innovative Adipose Tissue Fractionation for Transforming Fat into Specialized Components
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Injectable agents affecting subcutaneous fats.

David Lk Chen1, Joel L Cohen2,3,4, Jeremy B Green5,6

  • 1Department of Dermatology, University of Colorado, Aurora, USA.

Seminars in Cutaneous Medicine and Surgery
|November 14, 2015
PubMed
Summary
This summary is machine-generated.

Mesotherapy uses injections for local effects, with recent focus on fat contouring. Deoxycholate is effective for fat reduction, and new trials with salmeterol show promise.

Keywords:
fat contouringlipolysismesotherapy

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Area of Science:

  • Dermatology
  • Cosmetic Science
  • Pharmacology

Background:

  • Mesotherapy, originating in Europe in the 1950s, involves intradermal or subcutaneous injections for localized therapeutic effects.
  • Significant interest has emerged over the last two decades in mesotherapy for minimally invasive local fat contouring.
  • Initial mesotherapy for fat reduction utilized phosphatidylcholine, based on its theorized lipolytic properties.

Purpose of the Study:

  • To investigate the efficacy of mesotherapy agents for local fat contouring.
  • To clarify the active component responsible for adipolytic effects in mesotherapy.
  • To evaluate emerging treatments like salmeterol for lipolysis stimulation.

Main Methods:

  • Review of clinical trials and studies on mesotherapy agents for fat reduction.
  • Analysis of the pharmacological activity of phosphatidylcholine and deoxycholate in subcutaneous tissue.
  • Monitoring of ongoing clinical trials involving salmeterol for lipolysis.

Main Results:

  • Further studies revealed that deoxycholate, a solubilizing agent for phosphatidylcholine, is responsible for the observed adipolytic effects.
  • Clinical trials have confirmed the efficacy of a proprietary deoxycholate formulation for local fat contouring.
  • Preliminary results from ongoing trials using salmeterol, a beta-adrenergic agonist, show promising lipolytic effects.

Conclusions:

  • Deoxycholate is an effective agent for mesotherapy-induced local fat contouring.
  • Salmeterol represents a promising new agent for stimulating lipolysis via mesotherapy.
  • Mesotherapy continues to evolve as a minimally invasive option for body contouring.