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Related Concept Videos

Skin Cancer01:30

Skin Cancer

6.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer Therapies02:49

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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Mar 29, 2026

Electrochemotherapy of Tumours
03:57

Electrochemotherapy of Tumours

Published on: December 15, 2008

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Chemotherapy for Melanoma.

Melissa A Wilson1,2, Lynn M Schuchter3

  • 1Division of Hematology/Oncology, Department of Medicine, Hospital of the University of Pennsylvania, 3400 Civic Center Blvd, 16 Penn Tower, Philadelphia, PA, 19104, USA. Melissa.Wilson@nyumc.org.

Cancer Treatment and Research
|November 26, 2015
PubMed
Summary
This summary is machine-generated.

Chemotherapy remains valuable for advanced melanoma palliation, despite new therapies. While not improving survival, it offers palliative and long-term responses in specific cases, particularly for limb-isolated disease.

Keywords:
BiochemotherapyChemotherapyDacarbazineMelanomaTemozolomide

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Area of Science:

  • Oncology
  • Dermatology
  • Clinical Therapeutics

Background:

  • Chemotherapy was the primary treatment for advanced melanoma before recent therapeutic breakthroughs.
  • While single-agent dacarbazine showed some response, chemotherapy combinations have not improved overall survival.
  • Biochemotherapy (chemotherapy plus immunotherapy) demonstrated high clinical responses but increased toxicity without improving survival.

Purpose of the Study:

  • To review chemotherapy options for advanced-stage melanoma treatment and palliation.
  • To discuss clinical trials supporting chemotherapy recommendations.
  • To identify clinical scenarios where chemotherapy remains beneficial.

Main Methods:

  • Review of existing literature and clinical trials on chemotherapy for advanced melanoma.
  • Analysis of treatment outcomes, including objective responses, overall survival, and toxicity.
  • Evaluation of localized treatments like isolated limb perfusion/infusion.

Main Results:

  • Chemotherapy combinations have not shown improved overall survival compared to single-agent dacarbazine.
  • Localized treatments like isolated limb perfusion offer palliation and long-term responses for limb-isolated disease.
  • Chemotherapy can be useful for palliative treatment of refractory, progressive, or relapsed melanoma.

Conclusions:

  • Despite advances, chemotherapy retains a role in palliative care for advanced melanoma.
  • Localized therapies are effective for limb-isolated disease.
  • Chemotherapy's utility lies in managing specific patient populations with refractory or relapsed disease.