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Multiplex Detection of Bacteria in Complex Clinical and Environmental Samples using Oligonucleotide-coupled Fluorescent Microspheres

Multiplex Detection of Bacteria in Complex Clinical and Environmental Samples using Oligonucleotide-coupled Fluorescent Microspheres

Published on: October 23, 2011

Multiplex in vitro detection using SERS.

Stacey Laing¹, Kirsten Gracie¹, Karen Faulds¹

¹Centre for Molecular Nanometrology, WestCHEM, Pure and Applied Chemistry, University of Strathclyde, Technology and Innovation Centre, 99 George Street, Glasgow, G1 1RD, UK. karen.faulds@strath.ac.uk.

Chemical Society Reviews

|December 23, 2015

Summary

This summary is machine-generated.

Surface Enhanced Raman Scattering (SERS) enables quick, reliable detection of multiple disease targets in single samples. This technique offers sensitive and specific identification of DNA and proteins for improved disease diagnosis and monitoring.

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Area of Science:

Analytical Chemistry
Biotechnology
Medical Diagnostics

Background:

Accurate disease diagnosis and monitoring rely on detecting multiple disease-related targets.
Simultaneous detection from a single sample requires rapid and reliable methods.
Surface-Enhanced Raman Scattering (SERS) is an emerging technique for molecular detection.

Purpose of the Study:

To review the strengths of SERS for detecting target molecules in complex biological mixtures.
To highlight the clinical relevance of SERS in multiplexed detection of biological targets.
To discuss advancements in SERS for disease diagnosis and monitoring.

Main Methods:

Review of recent scientific literature on Surface-Enhanced Raman Scattering (SERS).
Focus on SERS applications for simultaneous detection of multiple analytes.
Analysis of SERS sensitivity and specificity for biological targets like DNA and proteins.

Main Results:

SERS facilitates sensitive and specific detection of biologically relevant molecules.
The technique allows for simultaneous detection of multiple targets from complex mixtures.
Recent advancements enable multiplexed detection with clinical relevance.

Conclusions:

SERS is a powerful tool for the simultaneous detection of multiple disease biomarkers.
The sensitivity and specificity of SERS are crucial for effective disease diagnosis and monitoring.
Combining SERS with multiplexing offers significant potential for clinical applications.