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A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects
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Ocular Behçet's Disease: Changing Patterns Over Time, Complications and Long-Term Visual Prognosis
Massimo Accorinti1, Francesca Romana Pesci1, Maria Pia Pirraglia1
1a Ocular Immunovirology Service, Department of Ophthalmology , Sapienza University of Rome , Rome , Italy.
Ocular Immunology and Inflammation
|January 5, 2016
Summary
Ocular Behçet
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Background:
- Behçet's disease (BD) is a multisystemic inflammatory disorder.
- Ocular involvement is a major cause of visual impairment in BD.
- Understanding temporal trends in ocular BD is crucial for patient management.
Purpose of the Study:
- To analyze demographic and clinical characteristics of Italian patients with ocular Behçet's disease.
- To investigate changes in clinical features and complications over time.
- To evaluate the impact of therapeutic interventions on visual outcomes.
Main Methods:
- Retrospective analysis of 385 Italian patients diagnosed with Behçet's disease between 1968 and 2011.
- Inclusion of 265 patients with a minimum follow-up of 12 months.
- Statistical analysis to identify trends in demographics, clinical manifestations, and complications.
Main Results:
- An increasing proportion of females and anterior uveitis cases were observed over time.
- A decrease in complete Behçet's disease and hypopyon was noted.
- Ocular complications like optic neuropathy and maculopathy decreased with increased immunosuppressive drug use, though visual acuity remained worse in males.
Conclusions:
- Significant shifts in ocular Behçet's disease clinical patterns occurred over 44 years.
- Immunosuppressive therapy effectively reduced ocular complications.
- While ocular BD incidence rises in females, males still face a poorer visual prognosis.
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