Compressed sensing cine imaging with high spatial or high temporal resolution for analysis of left ventricular...

Area of Science:

• Cardiovascular Imaging
• Magnetic Resonance Imaging
• Medical Physics

Background:

• Accurate quantification of left ventricular (LV) volumes is crucial for diagnosing and managing cardiovascular diseases.
• Compressed sensing (CS) cine MRI techniques offer potential for faster image acquisition compared to conventional methods.
• Evaluating novel CS sequences against established reference standards is essential for clinical adoption.

Purpose of the Study:

• To compare the reliability of two compressed sensing (CS) cine MRI sequences (high spatial resolution and high temporal resolution) against a standard steady-state free precession (SSFP) cine sequence.
• To assess the accuracy of LV volume quantification using these different MRI sequences.

Main Methods:

• LV short axis stacks were acquired from 16 healthy volunteers using a 1.5T MR system.
• Acquired sequences included SPARSE-SENSE HS (high spatial), SPARSE-SENSE HT (high temporal), and standard SSFP (reference).
• LV parameters were semi-automatically analyzed, and volumetric agreement was assessed using statistical tests and Bland-Altman analysis.

Main Results:

• SPARSE-SENSE HS showed small differences in stroke volume, ejection fraction, and myocardial mass compared to standard SSFP.
• SPARSE-SENSE HT demonstrated no significant differences in end-diastolic volume, stroke volume, or ejection fraction.
• Both CS sequences exhibited good agreement with standard SSFP, with a maximum bias of ≤ -8% in Bland-Altman analysis.

Conclusions:

• Compressed sensing cine MRI sequences, both high spatial and high temporal resolution, provide reliable left ventricular volume assessment.
• These novel CS sequences demonstrate good volumetric agreement with the reference standard SSFP sequence.
• CS cine MRI holds promise for efficient and accurate cardiac function evaluation.