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Probiotics as Antifungals in Mucosal Candidiasis
Victor H Matsubara1, H M H N Bandara2, Marcia P A Mayer3
1School of Dentistry, University of Queensland, Brisbane, Australia Department of Microbiology, Institute of Biomedical Sciences Department of Prosthodontics, School of Dentistry, University of São Paulo, Brazil.
Summary
Probiotics, especially lactobacilli, show promise in managing Candida infections by suppressing fungal growth and colonization. Clinical trials suggest benefits in reducing oral, vaginal, and enteric Candida, potentially aiding in preventing invasive fungal infections.
Area of Science:
- Mycology
- Microbiology
- Immunology
Background:
- Candida is an opportunistic pathogen causing mucosal and systemic infections.
- Antifungal drug resistance and side effects limit current treatments.
- Probiotics are explored as an alternative for candidiasis management.
Purpose of the Study:
- To analyze the efficacy of probiotics in controlling Candida colonization.
- To review evidence for probiotics in preventing and treating candidiasis.
Main Methods:
- In vitro studies assessing probiotic effects on Candida growth and biofilm.
- Clinical trials evaluating probiotic impact on Candida colonization and infection incidence.
Main Results:
- Probiotics, particularly lactobacilli, inhibit Candida growth and biofilm formation in vitro.
- Clinical trials demonstrate probiotic effectiveness in reducing oral, vaginal, and enteric Candida colonization.
- Probiotics may decrease the incidence of invasive fungal infections in critically ill patients.
Conclusions:
- Probiotics are a viable alternative for managing candidiasis.
- Lactobacilli show significant potential in combating Candida infections.
- Further research may establish probiotics as a key strategy against chronic mucosal candidiasis.
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