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Related Concept Videos

Bone Disorders01:29

Bone Disorders

7.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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What is the Skeletal System?01:02

What is the Skeletal System?

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Overview
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The Functions of the Skeletal System01:22

The Functions of the Skeletal System

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The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

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Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Preventing post-denosumab bone loss with zoledronate: a 2-year randomized trial in post-menopausal women without and with pre-exposure to bisphosphonates.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
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Publisher Correction: Probiotic Supplementation and Bone Health Parameters in Adults: A Systematic Review and Meta-Analysis.

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Health-related quality of life instruments for older persons with osteoporosis: a WHO-BOHEG systematic review of measurement properties for use in clinical trials and routine practice.

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Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
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[Bone diseases].

Brigitte Uebelhart, René Rizzoli

    Revue Medicale Suisse
    |March 8, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Calcium intake has minimal effect on bone health. Newer drugs like denosumab, abaloparatide, teriparatide, romosozumab, and odanacatib offer potent bone resorption inhibition and fracture risk reduction.

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    Area of Science:

    • Orthopedics and Bone Metabolism
    • Pharmacology of Bone Therapeutics

    Context:

    • Bone mineral density and fracture risk are influenced by various factors, with calcium intake having a limited impact.
    • Emerging therapeutic agents demonstrate significant potential in managing bone resorption and improving bone strength.

    Purpose:

    • To review current understanding and advancements in bone health therapeutics.
    • To update on the efficacy and application of various bone resorption inhibitors and anabolic agents.

    Summary:

    • Denosumab potently inhibits bone resorption, surpassing zoledronate. Abaloparatide and teriparatide (potentially via transdermal delivery) increase bone mineral density and reduce fracture incidence. Romosozumab and odanacatib enhance calculated bone strength.
    • Investigates optimal sequencing of treatments, suggesting sequential or combined denosumab and teriparatide may be beneficial, but not in the order of denosumab followed by teriparatide.
    • Provides updated information on rare bone diseases including fibrous dysplasia, Paget disease, and hypophosphatasia, alongside conditions like atypical femoral fracture and osteonecrosis of the jaw.

    Impact:

    • Highlights the superior efficacy of newer agents over traditional calcium supplementation for bone health.
    • Informs clinical practice regarding the selection and sequencing of osteoporosis treatments.
    • Contributes to the knowledge base for managing complex bone disorders and associated complications.