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Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research
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Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

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Circulating Tumor Cells.

Costanza Paoletti1, Daniel F Hayes2

  • 1Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan Health and Hospital System, 6312 Cancer Center University of Michigan, 1500 Medical Center Drive, 48109, Ann Arbor, MI, USA.

Advances in Experimental Medicine and Biology
|March 19, 2016
PubMed
Summary
This summary is machine-generated.

Circulating tumor cells (CTCs) offer a less invasive alternative to tissue biopsies for cancer monitoring. These "liquid biopsies" provide crucial prognostic and predictive information for breast cancer patients.

Keywords:
Breast cancerCharacterizationCirculating Tumor Cells (CTC)ClusterEnumerationPredictionPrognosis

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Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples
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Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarker Research

Background:

  • Circulating tumor cells (CTCs) are shed from primary and secondary tumors.
  • CTC enumeration is a validated prognostic factor for progression-free and overall survival in breast cancer.
  • CTCs offer advantages over tissue biopsy, including ease of collection and serial evaluation.

Purpose of the Study:

  • To highlight the prognostic and predictive value of CTCs in breast cancer.
  • To discuss the advancements in CTC phenotyping and genotyping.
  • To explore the potential of CTCs as pharmacodynamic monitoring tools.

Main Methods:

  • Review of existing literature on CTCs in breast cancer.
  • Analysis of CTC enumeration as a prognostic marker.
  • Discussion of emerging CTC phenotyping and genotyping techniques.

Main Results:

  • CTC enumeration is a robust independent prognostic factor for survival in breast cancer.
  • Advances in CTC analysis provide insights into treatment sensitivity and resistance.
  • Phenotypic marker changes in CTCs can serve as pharmacodynamic monitoring tools.

Conclusions:

  • CTCs function as