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RECIST Applied to Realistic Tumor Models.

Zachary H Levine1, Benjamin R Galloway1, Adele P Peskin2

  • 1Optical Technology Division, National Institute of Standards and Technology, Gaithersburg, MD 20899-8441.

Journal of Research of the National Institute of Standards and Technology
|March 19, 2016
PubMed
Summary

Response Evaluation Criteria in Solid Tumors (RECIST) measurements may inaccurately predict realistic tumor volumes. This study suggests RECIST performs less reliably for complex tumor shapes compared to simple ellipsoids in computed tomography scans.

Keywords:
RECISTtumor sizevolumetric measurementx-ray imaging

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Area of Science:

  • Oncology
  • Medical Imaging
  • Radiology

Background:

  • Response Evaluation Criteria in Solid Tumors (RECIST) is a standard method for assessing tumor size in medical imaging.
  • RECIST utilizes linear measurements, primarily from computed tomography (CT), to evaluate treatment response.
  • The accuracy of RECIST in reflecting true tumor volume, especially for complex geometries, remains an area of investigation.

Purpose of the Study:

  • To geometrically evaluate the predictive accuracy of RECIST for tumor volume.
  • To compare RECIST's performance in estimating the volume of realistic tumor models versus simple ellipsoidal shapes.
  • To assess the limitations of RECIST for complex tumor geometries.

Main Methods:

  • Utilizing purely geometrical considerations to model tumors as unions of ellipsoids.
  • Simulating randomly-oriented tumor models with varying complexities.
  • Analyzing the correlation between RECIST linear measurements and actual tumor volumes.

Main Results:

  • RECIST's ability to predict tumor volume was assessed using geometric models.
  • The study found that RECIST's accuracy is dependent on tumor shape.
  • Ellipsoidal models showed a higher correlation with RECIST predictions than more complex tumor structures.

Conclusions:

  • RECIST may underestimate or overestimate the true tumor volume for non-ellipsoidal, realistic tumor shapes.
  • Geometrical limitations suggest RECIST is less reliable for complex tumor geometries encountered in clinical practice.
  • Further research into volumetric assessment methods may be warranted for improved tumor response evaluation.