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[HYDROGEN SULFIDE DONOR, NAHS, RECOVERS CONSTITUTIVE NO SYNTHESIS AND ENDOTHELIUM-DEPENDENT RELAXATION OF ISOLATED
Fiziolohichnyi Zhurnal (Kiev, Ukraine : 1994)
|March 31, 2016
Summary
Hydrogen sulfide (H₂S) donor NaHS reverses age-related decline in blood vessel function in rats. NaHS treatment improves endothelium-dependent vasorelaxation and restores nitric oxide (NO) synthesis in aged aorta.
Area of Science:
- Cardiovascular Physiology
- Aging Research
- Endothelial Function
Context:
- Aging in rats is associated with oxidative and nitrosative stress in the aorta.
- This stress leads to uncoupling of endothelial nitric oxide synthase (eNOS), reducing nitric oxide (NO) production.
- These changes result in impaired endothelium-dependent vasorelaxation in aged aortic smooth muscles.
Purpose:
- To investigate the effects of the hydrogen sulfide (H₂S) donor, sodium hydrosulfide (NaHS), on aged rat aortas.
- To assess NaHS's impact on endothelium-dependent vasodilation, the free radical state, and eNOS coupling.
Summary:
- NaHS treatment inhibited the combined oxidative and nitrosative stress in aged rat aortas.
- This inhibition restored eNOS coupling, leading to the de novo synthesis of NO.
- NaHS significantly improved endothelium-dependent vasorelaxation, increasing acetylcholine-induced relaxation by 6.5-fold compared to controls.
Impact:
- NaHS can counteract age-related endothelial dysfunction by mitigating oxidative stress and restoring NO bioavailability.
- This study highlights the therapeutic potential of H₂S donors in managing vascular complications associated with aging.
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