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The microenvironment controls invadosome plasticity.

Julie Di Martino1, Elodie Henriet1, Zakaria Ezzoukhry1

  • 1Institut National de la Santé et de la Recherche Médicale, U1053, Bordeaux F-33076, France Université de Bordeaux, Bordeaux F-33076, France.

Journal of Cell Science
|April 1, 2016
PubMed
Summary
This summary is machine-generated.

Invadosomes, including podosomes and invadopodia, are actin structures crucial for matrix degradation. Their formation and activity are influenced by the microenvironment, particularly type I collagen, impacting cell behavior.

Keywords:
Cell invasionCollagenInvadopodiaInvadosomeMatrix degradationPodosome

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Area of Science:

  • Cell Biology
  • Biochemistry
  • Biophysics

Background:

  • Invadosomes are actin-based cellular structures essential for extracellular matrix (ECM) degradation.
  • This category encompasses podosomes in normal cells and invadopodia in tumor cells, often organized in dots or rosettes.
  • Their formation and activity are regulated by diverse internal and external stimuli.

Purpose of the Study:

  • To explore the influence of the microenvironment and matrix receptors on invadosome formation, dynamics, and degradative functions.
  • To highlight recent discoveries concerning the role of type I collagen fibrils in orchestrating invadosome organization.
  • To discuss the broader concept of invadosome plasticity and its physiological and pathological significance.

Main Methods:

  • Review and synthesis of current literature on invadosome biology.
  • Analysis of experimental findings related to microenvironmental cues and matrix receptor signaling.
  • Focus on studies investigating the impact of type I collagen on invadosome structure and function.

Main Results:

  • The microenvironment, especially type I collagen fibrils, significantly impacts invadosome formation and organization.
  • A novel linear organization of invadosomes induced by type I collagen has been identified.
  • Invadosome plasticity is a key feature, demonstrating adaptability to various stimuli and conditions.

Conclusions:

  • Invadosome behavior is intricately linked to the physical and biochemical properties of the surrounding microenvironment.
  • Matrix receptors play a critical role in mediating the effects of the microenvironment on invadosomes.
  • Understanding invadosome plasticity is crucial for elucidating their roles in both normal physiological processes and pathological conditions like cancer.