Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

812
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
812
Dysrhythmias II: Classification of Tachyarrhythmias01:28

Dysrhythmias II: Classification of Tachyarrhythmias

758
Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...
758
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

3.5K
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
3.5K
Dysrhythmias III: Characteristics of Dysrhythmias01:29

Dysrhythmias III: Characteristics of Dysrhythmias

662
Dysrhythmias, also known as arrhythmias, are irregular heart rhythms that result from abnormal electrical activity in the heart, affecting its ability to circulate blood efficiently. Tachyarrhythmias, a subset of dysrhythmias, are characterized by abnormally fast heart rates exceeding 100 beats per minute. Here are some types of tachyarrhythmias with their distinct ECG features:Sinus Tachycardia:Sinus tachycardia presents a regular heart rhythm with an increased rate of 101-180 beats per...
662
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

643
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
643
Increased pulse rate01:17

Increased pulse rate

1.4K
Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tricuspid Regurgitation and Impact of Surgical Valve Intervention in the Single Ventricle Reconstruction Trial.

Pediatric cardiology·2026
Same author

Calcific aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk.

Basic research in cardiology·2025
Same author

Comparative analysis of cryoballoon versus radiofrequency catheter ablation in atrial fibrillation patients with impaired left ventricular ejection fraction.

International journal of cardiology. Heart & vasculature·2025
Same author

Pneumologie (Stuttgart, Germany)·2024
Same author

[Chronic obstructive pulmonary disease (COPD): eosinophilia and novel drug therapies].

Innere Medizin (Heidelberg, Germany)·2024
Same author

Coronary intravascular lithotripsy and rotational atherectomy for severely calcified stenosis: Results from the ROTA.shock trial.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2023

Related Experiment Video

Updated: Mar 20, 2026

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS
08:12

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Published on: November 26, 2018

10.8K

Heart Rate Variability and Arrhythmic Burden in Pulmonary Hypertension.

C Witte1, J U Meyer Zur Heide Genannt Meyer-Arend1, R Andrié1

  • 1Department of Internal Medicine II, Cardiology, Pneumology and Angiology, University Hospital Bonn, 25 Sigmund-Freud-Straße, Bonn, 53105, Germany.

Advances in Experimental Medicine and Biology
|June 1, 2016
PubMed
Summary

Sudden cardiac death is a major risk in pulmonary hypertension (PH). Heart rate variability (HRV) assessment reveals significant autonomic dysfunction and increased arrhythmia risk, particularly in pulmonary arterial hypertension (PAH).

Keywords:
Atrial fibrillationEchocardiographyFrequency-domain analysisRight heart catheterizationSudden cardiac deathSystolic pulmonary arterial pressureTime-domain analysis

More Related Videos

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

935
Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
08:34

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat

Published on: November 18, 2018

7.8K

Related Experiment Videos

Last Updated: Mar 20, 2026

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS
08:12

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Published on: November 26, 2018

10.8K
Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

935
Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
08:34

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat

Published on: November 18, 2018

7.8K

Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Autonomic Nervous System Research

Background:

  • Sudden cardiac death is a significant mortality cause in pulmonary hypertension (PH).
  • Heart rate variability (HRV) alterations indicate cardiac autonomic dysfunction and predict arrhythmic events.
  • The clinical utility of HRV assessment in various PH subtypes remains to be fully elucidated.

Purpose of the Study:

  • To investigate the clinical value of heart rate variability (HRV) assessment in patients with pulmonary hypertension (PH).
  • To compare HRV and arrhythmic burden across different PH subtypes: pulmonary arterial hypertension (PAH), chronic thromboembolic PH (CTEPH), and COPD-induced PH.
  • To identify specific HRV alterations and arrhythmia patterns associated with increased risk in PH patients.

Main Methods:

  • Prospective study of 64 PH patients (25 PAH, 11 CTEPH, 28 COPD-induced PH) and 31 healthy controls.
  • 24-hour Holter electrocardiogram recordings for time- and frequency-domain HRV analysis.
  • Assessment of premature atrial and ventricular contractions (PACs and PVCs) using manual and automatic methods.

Main Results:

  • PAH patients exhibited significantly higher mean heart rate, increased PVC burden, and reduced HRV parameters (SDNN, SDANN, VLF, LF/HF ratio, Total Power) compared to controls.
  • CTEPH patients showed a significantly higher PVC burden but no significant HRV alterations compared to controls.
  • COPD-induced PH patients demonstrated significant differences in PAC count and frequency-domain HRV compared to controls.

Conclusions:

  • Pulmonary arterial hypertension (PAH) is strongly associated with significant heart rate variability alterations and a high burden of ventricular arrhythmias.
  • These findings suggest a heightened risk for malignant arrhythmic events in PAH patients.
  • HRV assessment provides valuable insights into autonomic dysfunction and arrhythmia risk across different PH subtypes.