Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Association Areas of the Cortex01:21

Association Areas of the Cortex

8.6K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
8.6K
Total Internal Reflection Fluorescence Microscopy01:05

Total Internal Reflection Fluorescence Microscopy

10.9K
Total internal reflection fluorescence microscopy or TIRF is an advanced microscopic technique used to visualize fluorophores in samples close to a solid surface with a higher refractive index, such as a glass coverslip. TIRF only allows fluorophores in proximity to the solid surface to be excited. When light from a medium with a lower refractive index (such as air) hits the glass coverslip at a critical angle, the light undergoes total internal reflection stead of passing through the glass.
10.9K
Discrete-Time Fourier Series01:20

Discrete-Time Fourier Series

601
The Discrete-Time Fourier Series (DTFS) is a fundamental concept in signal processing, serving as the discrete-time counterpart to the continuous-time Fourier series. It allows for the representation and analysis of discrete-time periodic signals in terms of their frequency components. Unlike its continuous counterpart, which utilizes integrals, the calculation of DTFS expansion coefficients involves summations due to the discrete nature of the signal.
For a discrete-time periodic signal x[n]...
601
Fast Fourier Transform01:10

Fast Fourier Transform

817
The Fast Fourier Transform (FFT) is a computational algorithm designed to compute the Discrete Fourier Transform (DFT) efficiently. By breaking down the calculations into smaller, manageable sections, the FFT significantly reduces the computational complexity involved. Direct computation of an N-point DFT requires N2 complex multiplications, whereas the FFT algorithm needs only (N/2)log⁡2N multiplications, offering a much faster performance.
The computational efficiency of the FFT becomes...
817
Discrete-time Fourier transform01:26

Discrete-time Fourier transform

969
The Discrete-Time Fourier Transform (DTFT) is an essential mathematical tool for analyzing discrete-time signals, converting them from the time domain to the frequency domain. This transformation allows for examining the frequency components of discrete signals, providing insights into their spectral characteristics. In the DTFT, the continuous integral used in the continuous-time Fourier transform is replaced by a summation to accommodate the discrete nature of the signal.
One of the notable...
969
Field Effect Transistor01:29

Field Effect Transistor

1.0K
Field-effect transistors (FETs) are integral to electronic circuits and distinguished by their three-terminal setup: the gate, drain, and source. These transistors operate as unipolar devices, which utilize either electrons or holes as charge carriers, in contrast to bipolar transistors, which use both types of carriers. The primary function of the FET is to modulate the flow of these carriers from the source to the drain through a channel. The voltage difference between the gate and source...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HKDC1 contributes to aberrant lysosome-mitochondria contact in Niemann-Pick disease type C.

bioRxiv : the preprint server for biology·2026
Same author

UV induces common cutaneous amyloid-like melanosomal protein aggregates.

bioRxiv : the preprint server for biology·2025
Same author

Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling.

EMBO reports·2025
Same author

Structural basis for mTORC1 activation on the lysosomal membrane.

Nature·2025
Same author

ATG conjugation-dependent/independent mechanisms underlie lysosomal stress-induced TFEB regulation.

The Journal of cell biology·2025
Same author

TFEBexplorer: An integrated tool to study genes regulated by the stress-responsive Transcription Factor EB.

Autophagy reports·2025
Same journal

FAM122A inhibition of PP2A-B55 through a bipartite binding mechanism.

Journal of cell science·2026
Same journal

Disentangling the response to lysosomal damage.

Journal of cell science·2026
Same journal

The force, form and function of the nucleus.

Journal of cell science·2026
Same journal

The nucleus-vacuole junction at a glance.

Journal of cell science·2026
Same journal

Loss of INPP5E affects photoreceptor outer segment membrane biogenesis in iPSC-derived human retinal organoids.

Journal of cell science·2026
Same journal

Brinker regulates reciprocal outcomes of BMP signal between stem cells and differentiating cells.

Journal of cell science·2026
See all related articles

Related Experiment Video

Updated: Jan 2, 2026

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis
03:53

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis

Published on: December 29, 2023

1.2K

TFEB at a glance.

Gennaro Napolitano1, Andrea Ballabio2

  • 1Telethon Institute of Genetics and Medicine (TIGEM), 80131 Naples, Italy.

Journal of Cell Science
|June 3, 2016
PubMed
Summary
This summary is machine-generated.

Transcription factor EB (TFEB) controls cellular processes like autophagy and lysosome function. Modulating TFEB activity offers potential therapeutic strategies for neurodegenerative diseases by clearing pathogenic factors.

Keywords:
AutophagyLysosomal storage disordersLysosomesMiT familyTFE3TFEBmTOR

More Related Videos

Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT
10:30

Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT

Published on: September 2, 2015

10.7K
A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

24.3K

Related Experiment Videos

Last Updated: Jan 2, 2026

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis
03:53

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis

Published on: December 29, 2023

1.2K
Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT
10:30

Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT

Published on: September 2, 2015

10.7K
A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

24.3K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Neuroscience

Background:

  • Transcription factor EB (TFEB) regulates lysosomal biogenesis and autophagy.
  • TFEB activity is controlled by mTOR-mediated phosphorylation at the lysosome.
  • Lysosome-to-nucleus signaling via TFEB impacts cellular energy metabolism and lipid catabolism.

Purpose of the Study:

  • To provide an overview of TFEB function.
  • To discuss the role of TFEB in human diseases.
  • To highlight TFEB's therapeutic potential.

Main Methods:

  • Literature review of recent research on TFEB.
  • Analysis of in vivo studies involving TFEB.
  • Examination of TFEB's role in disease models.

Main Results:

  • TFEB regulates key cellular processes including autophagy and lysosome function.
  • TFEB activity is modulated by lysosomal signaling pathways.
  • TFEB promotes the clearance of pathogenic factors in disease models.

Conclusions:

  • TFEB is a crucial regulator of cellular homeostasis.
  • TFEB modulation is a promising therapeutic avenue for diseases like Parkinson's and Alzheimer's.
  • Further research into TFEB's role in human diseases is warranted.