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Maintenance of High Cytochrome P450 Expression in HepaRG Cell Spheroids in DMSO-Free Medium
A V Aleksandrova1, O A Burmistrova2, K A Fomicheva3
1BioClinicum Research and Production Center, Moscow, Russia. a.aleksandrova@bioclinicum.com.
Bulletin of Experimental Biology and Medicine
|June 7, 2016
Abstract:
We studied the effects of DMSO and fibroblasts during HepaRG cell spheroid formation and conditions of their subsequent culturing on the levels of mRNA of the major cytochromes P450. A protocol of spheroid formation from differentiated HepaRG cells and their culturing in serum- and DMSO-free medium is developed.
