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Related Concept Videos

Overview Of Cell Separation And Isolation01:20

Overview Of Cell Separation And Isolation

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Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.
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Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering
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Translating microfluidics: Cell separation technologies and their barriers to commercialization.

C Wyatt Shields1,2, Korine A Ohiri1,3, Luisa M Szott1,2

  • 1NSF Research Triangle Materials Research Science and Engineering Center, Duke University, Durham, North Carolina, 27708.

Cytometry. Part B, Clinical Cytometry
|June 11, 2016
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Summary

Microfluidic cell sorting offers advanced, miniaturized solutions for analyzing cells. Overcoming challenges in commercialization and user interface design is key to their widespread clinical adoption.

Keywords:
cell sortingcommercial translationflow cytometrylab on a chipmicrofluidic

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Area of Science:

  • Biotechnology
  • Medical Devices
  • Cell Biology

Background:

  • Microfluidic cell sorting technologies provide high-performance, miniaturized alternatives to traditional systems.
  • These devices utilize diverse physical phenomena for cell manipulation and analysis, including magnetic traps and sound waves.
  • Applications range from single-cell chemotherapeutic assessment to toxicity screenings and drug interaction studies.

Purpose of the Study:

  • Identify leading microfluidic cell sorting technologies with clinical translation potential.
  • Examine the primary barriers hindering the routine clinical implementation of these devices.
  • Provide a roadmap of essential criteria for overcoming these barriers and facilitating clinical adoption.

Main Methods:

  • Review of current microfluidic cell sorting technologies.
  • Analysis of commercialization and clinical translation challenges.
  • Identification of key criteria for successful clinical integration.

Main Results:

  • Despite significant innovation, few microfluidic cell sorting devices have achieved commercial success or widespread clinical use.
  • Key barriers include a saturated patent landscape and complex user interfaces.
  • Several leading technologies are identified as promising for clinical translation.

Conclusions:

  • Microfluidic cell sorting holds transformative potential for clinical laboratories.
  • Addressing commercialization and usability challenges is crucial for widespread adoption.
  • Successful translation will enable advanced cellular analysis for disease study and diagnostics.