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Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
Published on: August 31, 2022
NORMAL TISSUE REACTIONS TO CHRONIC RADIATION EXPOSURE IN MAN
1Urals Research Center for Radiation Medicine, Chelyabinsk, Russian Federation, Chelyabinsk State University, No. 68-A, Vorovsky St., 454076 Chelyabinsk, Russia Akleyev@urcrm.ru.
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This paper presents an overview of radiobiological dependences governing the occurrence of tissue (organ) reactions that determine the outcomes of chronic exposure to low-LET ionizing radiation (IR) in humans. The mechanisms involved in the development of tissue reactions (TRs) to long-term exposures to IR and radioadaptation are considered. The overview describes the reactions of the haematopoietic, immune, nervous, reproductive and endocrine systems, lungs, skin and crystalline lens to chronic radiation exposure, which are of fundamental importance in view of radiation protection. It is shown that the individual's physiological tissue (organ) reserve, and also that induced by radiation exposure at low-dose rates are of great significance in the context of TR development.
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