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Boundary Element Method for Reconstructing Absorption and Diffusion Coefficients of Biological Tissues in DOT/MicroCT
Wenhao Xie1,2, Yong Deng3,4, Lichao Lian1,2
1Wuhan National Laboratory for Optoelectronics, Britton Chance Center for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, 430074, China.
Advances in Experimental Medicine and Biology
|August 16, 2016
Summary
This study introduces a new method combining Diffuse Optical Tomography (DOT) and MicroCT imaging. The boundary element method improves the accuracy and stability of reconstructing tissue optical properties.
Area of Science:
- Biomedical Optics
- Medical Imaging
- Computational Biology
Background:
- Diffuse Optical Tomography (DOT) and MicroCT are crucial for obtaining biological tissue information.
- Accurate reconstruction of absorption and diffusion coefficients is vital for understanding tissue function.
Purpose of the Study:
- To develop and validate a novel reconstruction scheme for absorption and diffusion coefficients using DOT/MicroCT multimodality imaging.
- To leverage structural priors from MicroCT to enhance DOT reconstruction accuracy.
Main Methods:
- Utilized the boundary element method (BEM) to solve the forward problem in DOT.
- Integrated MicroCT-derived structural information as a prior for BEM.
- Employed the Levenberg-Marquardt algorithm for inverse problem reconstruction.
- Focused on single-value reconstruction within organs to mitigate ill-posedness.
Main Results:
- The BEM-based approach simplifies calculations by requiring only surface meshing.
- Reconstruction of a single value per organ improved noise stability and reduced ill-posedness.
- Successfully reconstructed absorption and diffusion coefficients for biological tissues.
Conclusions:
- The proposed boundary element method-based reconstruction offers a robust scheme for determining tissue optical properties.
- This multimodality approach enhances the capabilities of DOT/MicroCT imaging for biological tissue analysis.
