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AC Electrokinetic Phenomena Generated by Microelectrode Structures
Published on: July 28, 2008
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AC electrokinetic drug delivery in dentistry using an interdigitated electrode assembly powered by inductive coupling
Chris S Ivanoff1,2, Jie Jayne Wu3, Hadi Mirzajani3,4
1Department of Bioscience Research, College of Dentistry, University of Tennessee Health Science Center, 875 Union Avenue, Memphis, TN, 38163, USA. civanoff@uthsc.edu.
Biomedical Microdevices
|August 28, 2016
Summary
This study introduces wireless AC electrokinetics (ACEK) drug delivery using interdigitated electrode arrays (IDE) for dental applications. The novel device enhances drug transport and whitening efficacy wirelessly, improving safety and effectiveness.
Area of Science:
- Biomedical Engineering
- Dental Technology
- Drug Delivery Systems
Background:
- AC electrokinetics (ACEK) shows promise for enhanced drug delivery into teeth.
- Wired intraoral ACEK devices present safety risks to patients.
- Wireless drug delivery is needed to improve dental treatment safety and efficacy.
Purpose of the Study:
- To develop and validate a novel wireless ACEK device for intraoral drug delivery.
- To assess the efficacy of the wireless device in enhancing drug transport and dental whitening.
- To demonstrate the potential of wireless ACEK for improved dental drug delivery.
Main Methods:
- A novel interdigitated electrode arrays (IDE) assembly powered by inductive coupling was designed.
- The device generated amplitude-modulated (AM) signals for wireless power transfer and ACEK induction.
- Device efficacy was validated using microspheres, various drugs, and a dental bleaching application.
Main Results:
- The IDE system successfully motivated various particles and drugs wirelessly.
- Dental whitening was enhanced by 215% (specular optic) and 194% (specular optic excluded) compared to diffusion.
- Carbamide peroxide absorbance was doubled compared to diffusion, as measured by spectroscopy.
Conclusions:
- Wireless ACEK using IDE offers a safe and effective method for intraoral drug delivery.
- This technology has the potential to significantly improve drug transport and treatment outcomes in dentistry.
- The wireless approach overcomes the safety limitations of wired intraoral devices.
