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The Esophagiome: concept, status, and future perspectives.
Hans Gregersen1,2, Donghua Liao3, James G Brasseur4
1GIOME, College of Bioengineering, Chongqing University, China. hag@giome.org.
Annals of the New York Academy of Sciences
|August 30, 2016
Summary
The Esophagiome concept uses multiscale mathematical models to holistically study esophageal function, from cellular processes to biomechanical transport. This approach aims to analyze normal and diseased states, aiding diagnostics and treatment predictions.
Area of Science:
- Physiology
- Biomedical Engineering
- Computational Biology
Background:
- The Esophagiome concept offers a holistic, multiscale approach to understanding esophageal function.
- It integrates cellular and muscle physiology with mechanical responses for fluid transport and mixing.
Purpose of the Study:
- To review the Esophagiome concept and its application in esophageal research.
- To highlight the role of multiscale mathematical models in analyzing esophageal function and disease.
Main Methods:
- Development and application of multiscale mathematical models.
- Creation of a "virtual esophagus" modeling framework.
- Quantitative analysis of normal versus pathophysiological esophageal function.
Main Results:
- Models incorporate anatomical details, sensory-motor properties, and biomechanical functions.
- Focus on bolus transport and gastrointestinal fluid mixing.
- Provides a framework for contrasting normal and diseased esophageal function.
Conclusions:
- Advanced models can predict therapeutic outcomes for surgical and endoscopic interventions.
- The Esophagiome research aims to facilitate clinical diagnostics and treatment strategies.
- Future models will enhance our understanding of esophageal biomechanics and disease.
Keywords:
EsophagiomeGIOMEbiomechanicsesophagogastric junctionesophagusgastrointestinalmodelingneurophysiologyperistalsisMore Related Videos
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