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Updated: Mar 14, 2026
Confocal Time Lapse Imaging as an Efficient Method for the Cytocompatibility Evaluation of Dental Composites
Published on: November 9, 2014
Cytotoxic effects of bulk fill composite resins on human dental pulp stem cells
Reyhan Şişman1, Ayça Aksoy, Muhammet Yalçın
1Department of Restorative Dentistry, Faculty of Dentistry, University of Inonu.
Abstract:
Five bulk fill composite resins, including SDR, Tetric EvoCeram Bulk Fill (TEC), X-trafil (XTF), Sonic Fill (SF), Filtek Bulk Fill (FBF), were used in this study. Human dental pulp stem cells were cultured in 12-well culture dishes (3 × 104 cells per cm(2)) and stored in an incubator at 37°C and 5% CO2 for 1 day. On days 1, 7, 14, and 21 of co-culture, viable cells were measured using a WST-1 assay. Lower cell viability was observed with XTF and SDR bulk fill composite resins compared to the control group during the WST-1 assay. Although bulk fill composite resins provide advantages in practical applications, they are limited by their cytotoxic properties. (J Oral Sci 58, 299-305, 2016).
