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Piperine and Its Role in Chronic Diseases
Giuseppe Derosa1,2,3,4, Pamela Maffioli5,6,7, Amirhossein Sahebkar8,9
1Department of Internal Medicine and Therapeutics, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, P.le C. Golgi 2, 27100, Pavia, Italy. giuseppe.derosa@unipv.it.
Advances in Experimental Medicine and Biology
|September 28, 2016
Summary
Piperine, an alkaloid from black pepper, shows significant health benefits for chronic diseases. It helps reduce insulin resistance, inflammation, and fatty liver disease.
Area of Science:
- Pharmacology
- Natural Products Chemistry
- Nutritional Science
Background:
- Piperine is a key alkaloid found in Piper species, notably black pepper.
- It is responsible for the pungent taste of black pepper and possesses various pharmacological properties.
- Chronic diseases represent a significant global health burden, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review the therapeutic effects of piperine, both as a standalone agent and in combination therapies.
- To explore piperine's potential in managing and mitigating chronic diseases.
- To highlight piperine's role in improving metabolic and inflammatory conditions.
Main Methods:
- Literature review of studies investigating piperine's effects.
- Analysis of research on piperine's pharmacological actions.
- Examination of clinical and preclinical data on piperine in chronic disease models.
Main Results:
- Piperine demonstrates anti-inflammatory and antioxidant properties.
- Studies indicate piperine can reduce insulin resistance and improve hepatic steatosis.
- Combinations of piperine with other compounds may enhance therapeutic outcomes.
Conclusions:
- Piperine exhibits promising therapeutic potential for various chronic diseases.
- Its anti-inflammatory and metabolic regulatory effects warrant further investigation.
- Piperine represents a valuable natural compound for developing adjunct therapies for chronic conditions.
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