Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

1.2K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.2K
Vaccinations01:51

Vaccinations

53.1K
Overview
53.1K
Preventive Healthcare Services01:30

Preventive Healthcare Services

2.3K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
2.3K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

247
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
247
Cross-reactivity00:42

Cross-reactivity

33.7K
Overview
33.7K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

2.2K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Partner change, birth interval and risk of pre-eclampsia: a paradoxical triangle.

Paediatric and perinatal epidemiology·2007
Same author

Partner change and perinatal outcomes: a systematic review.

Paediatric and perinatal epidemiology·2007
Same author

A controversial tumor marker: is SM22 a proper biomarker for gastric cancer cells?

Journal of proteome research·2007
Same author

A strategy for high-throughput analysis of levosimendan and its metabolites in human plasma samples using sequential negative and positive ionization liquid chromatography/tandem mass spectrometric detection.

Rapid communications in mass spectrometry : RCM·2007
Same author

[Leukemic cell apoptosis induced by anti-human DR5 monoclonal antibody mDRA-6].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology·2007
Same author

[Infection of intervertebral space and the interventional therapy].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2007
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Mar 13, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

10.4K

Prophylactic Hepatitis E Vaccine.

Jun Zhang1, Qinjian Zhao2, Ningshao Xia2

  • 1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, China. zhangj@xmu.edu.cn.

Advances in Experimental Medicine and Biology
|October 15, 2016
PubMed
Summary
This summary is machine-generated.

Hepatitis E virus (HEV) infection poses a significant global health challenge, particularly for vulnerable groups. Recombinant vaccines targeting the HEV capsid protein show promise for effective prevention.

Keywords:
EfficacyEpitopeImmunogenicityNeutralizing antibodyVaccine

More Related Videos

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
09:12

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods

Published on: May 11, 2018

7.4K
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

3.5K

Related Experiment Videos

Last Updated: Mar 13, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

10.4K
Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
09:12

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods

Published on: May 11, 2018

7.4K
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

3.5K

Area of Science:

  • Hepatology
  • Virology
  • Vaccinology

Background:

  • Hepatitis E is an emerging global health concern with severe outcomes in specific populations.
  • Existing methods for developing inactivated or attenuated vaccines are hindered by the lack of efficient Hepatitis E virus (HEV) cell culture systems.
  • Vaccination is the most effective strategy for preventing HEV infection.

Purpose of the Study:

  • To explore recombinant vaccine approaches for Hepatitis E prevention.
  • To identify and target neutralizing sites within the HEV capsid protein (pORF2).
  • To evaluate the safety and efficacy of HEV vaccine candidates.

Main Methods:

  • Development of recombinant vaccine candidates based on the HEV pORF2 protein.
  • Pre-clinical testing in primate models to assess protective potential.
  • Clinical trials in human adults to evaluate safety and efficacy.

Main Results:

  • Recombinant pORF2-based vaccine candidates demonstrated protective potential in primates.
  • Two vaccine candidates were well-tolerated and highly efficacious in human trials.
  • The first HEV vaccine, Hecolin® (HEV 239), was licensed and launched in China in 2012.

Conclusions:

  • Recombinant vaccines targeting the HEV pORF2 protein are a viable strategy for Hepatitis E prevention.
  • Clinical studies confirm the safety and high efficacy of these novel vaccines.
  • The development of Hecolin® represents a significant advancement in controlling the global burden of Hepatitis E.