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Updated: Mar 11, 2026

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma

Published on: November 5, 2020

Screening for Pancreatic Cancer.

Saowanee Ngamruengphong¹, Marcia Irene Canto¹

¹Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Blalock 407, Baltimore, MD 21287, USA.

The Surgical Clinics of North America

|November 21, 2016

Summary

Pancreatic cancer (PC) is deadly, often diagnosed too late for surgery. Early detection through screening may be possible for individuals with genetic risk factors for pancreatic cancer.

Keywords:

Familial pancreatic cancer Intraductal papillary mucinous neoplasm Pancreatic cancer Pancreatic cyst Pancreatic intraepithelial neoplasia Screening

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DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens

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Published on: February 1, 2020

Area of Science:

Oncology
Genetics
Epidemiology

Background:

Pancreatic cancer (PC) is a leading cause of cancer death, with surgical resection being the only cure.
Most patients present with unresectable disease, emphasizing the need for early detection.
Population-based screening for PC is not cost-effective.

Purpose of the Study:

To provide an overview of the epidemiology and genetic factors of familial pancreatic cancer.
To discuss current diagnostic and management strategies for hereditary pancreatic cancer.
To identify potential targets for pancreatic cancer screening programs.

Main Methods:

Review of epidemiological data on familial pancreatic cancer.
Analysis of genetic syndromes associated with increased PC risk.
Discussion of diagnostic tools and clinical management guidelines.

Main Results:

Familial clustering of PC suggests a significant genetic component.
Specific genetic syndromes are linked to a higher incidence of PC.
Targeted screening in high-risk families may improve early detection rates.

Conclusions:

Individuals with a family history or genetic predisposition are key candidates for PC screening.
Early detection and management in at-risk populations can potentially improve outcomes.
Further research into genetic risk factors and screening efficacy is warranted.