HURTLE CELLS IMMUNOHISTOCHEMICAL ACTIVITIES IN HASHIMOTO THYROIDITIS PARENCHYMA

Area of Science:

• Endocrinology
• Pathology
• Immunology

Background:

• Hürthle cells are crucial in thyroid pathology.
• Distinguishing their role in Hashimoto's thyroiditis and Riedel's struma is important.

Purpose of the Study:

• To evaluate Hürthle cell morphology and activity in Hashimoto's thyroiditis versus Riedel's struma.
• To identify specific markers for Hürthle cell activity in these conditions.

Main Methods:

• Histological and immunohistochemical analysis of 89 thyroidectomy specimens.
• Detection of TSH receptors, TTF-1, S-100 protein, anti-TPO, and anti-TG levels.

Main Results:

• Hashimoto's thyroiditis showed Hürthle cell clusters and adenomatous growth with elevated anti-TPO/anti-TG.
• Riedel's struma exhibited fibrosing inflammation.
• Hashimoto cases displayed positive TTF-1/S-100 and negative TSH receptor expression, suggesting hypothyroid-induced changes and neuroectodermal activity.

Conclusions:

• Hürthle cell changes in Hashimoto's thyroiditis are linked to hypothyroid-induced parenchymal disorganization and neuroectodermal cell activity.
• Distinct morphological and molecular profiles differentiate Hürthle cell involvement in Hashimoto's thyroiditis and Riedel's struma.