Recent advances on the encoding and selection methods of DNA-encoded chemical library
Bingbing Shi1, Yu Zhou1, Yiran Huang2
1Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China; Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region.
Abstract:
DNA-encoded chemical library (DEL) has emerged as a powerful and versatile tool for ligand discovery in chemical biology research and in drug discovery. Encoding and selection methods are two of the most important technological aspects of DEL that can dictate the performance and utilities of DELs. In this digest, we have summarized recent advances on the encoding and selection strategies of DEL and also discussed the latest developments on DNA-encoded dynamic library, a new frontier in DEL research.
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