Related Experiment Videos
Exercise response in young women with mitral valve prolapse
1Cardiac Rehabilitation Institute, Chaim Sheba Medical, Tel Hashomer, Israel.
Chest
|November 1, 1989
Summary
Young women with mitral valve prolapse (MVP) show signs of autonomic nervous system imbalance, regardless of physical symptoms. This dysfunction impacts exercise response and cardiac function, suggesting a need for further investigation in MVP patients.
Area of Science:
- Cardiology
- Autonomic Neuroscience
- Exercise Physiology
Background:
- Autonomic nervous system (ANS) dysfunction can affect cardiovascular health.
- Mitral valve prolapse (MVP) is a common cardiac condition, particularly in young women.
- The relationship between MVP, ANS function, and exercise response requires further elucidation.
Purpose of the Study:
- To investigate potential autonomic nervous system dysfunction in young women with MVP.
- To assess exercise response in MVP patients and compare it to healthy controls.
- To determine if physical symptoms or specific clinical findings correlate with ANS dysfunction in MVP.
Main Methods:
- Exercise response was assessed in 198 young women with echocardiographically documented MVP.
- A standardized exercise test was used to evaluate physiological parameters.
- MVP patients were compared to 105 age- and sex-matched healthy subjects.
Main Results:
- MVP patients exhibited higher resting and exercise heart rate, blood pressure, and rate-pressure product compared to controls.
- Significantly lower physical working capacity (PWC170) was observed in MVP patients.
- Increased incidence of arrhythmias, ST-T wave changes, and prolonged corrected QT interval were noted in MVP group, unrelated to symptoms.
Conclusions:
- Young women with MVP demonstrate evidence of autonomic nervous system imbalance.
- This imbalance is present irrespective of physical symptoms or specific clinical findings.
- Findings suggest a need for considering ANS evaluation in managing young women with MVP.