Related Experiment Video
Updated: Mar 7, 2026
06:27
Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
17.4K
Sumoylation Modulates the Susceptibility to Type 1 Diabetes
Jing Zhang1, Zhishui Chen1, Zhiguang Zhou2
1The Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, Key Laboratory of Organ Transplantation, Ministry of Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China.
Advances in Experimental Medicine and Biology
|February 16, 2017
Summary
The SUMO4 gene is a potential susceptibility gene for type 1 diabetes (T1D). Genetic studies show SUMO4 association with T1D in Asian populations, suggesting a role in disease development.
Area of Science:
- Genetics
- Immunology
- Molecular Biology
Background:
- Type 1 diabetes (T1D) susceptibility arises from complex gene-environment interactions.
- Over 50 T1D susceptibility regions identified, but specific genes remain elusive.
- The SUMO4 gene was cloned in the IDDM5 region (chromosome 6q25) in 2004.
Purpose of the Study:
- To summarize and validate genetic data on SUMO4 association with T1D.
- To discuss functional properties and molecular mechanisms of SUMO4 in T1D development.
Main Methods:
- Review of published genetic association studies of SUMO4 and T1D.
- Analysis of functional data related to SUMO4 and sumoylation.
Main Results:
- SUMO4 association with T1D consistently confirmed in Asian populations.
- Controversial findings in Caucasian populations may stem from genetic heterogeneity.
- SUMO4 presents strong genetic and functional evidence as a T1D susceptibility gene.
Conclusions:
- SUMO4 is a significant candidate gene for type 1 diabetes susceptibility.
- Altered sumoylation by SUMO4 may modulate T1D pathogenesis.
- Further research is warranted to elucidate SUMO4's precise role and mechanisms in T1D.
More Related Videos
Related Concept Videos
01:22Diabetes Mellitus: Overview and Type I Subtype
5.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.7K
01:20Pathophysiology of Diabetes
4.0K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.0K
01:22Diabetes Mellitus: Type 2 and Gestational
5.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.3K
01:19Psychoneuroimmunology: Diabetes and Cancer
567
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
567
01:36Carbohydrate Metabolism
14.7K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
14.7K
01:33Pleiotropy
43.7K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.7K