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Dependence between LD50 for Rodents and LC50 for Adult Fish and Fish Embryos.
K V Zolotarev1, N F Belyaeva2, A N Mikhailov2
1V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia. fireaxe@mail.ru.
Bulletin of Experimental Biology and Medicine
|March 1, 2017
Summary
This study links chemical lipophilicity (lgP) to toxicity in aquatic organisms versus mammals. It found correlations between lipophilicity and toxicity ratios for fish and rodent models, aiding environmental risk assessment.
Area of Science:
- Environmental Toxicology
- Chemical Risk Assessment
- Ecotoxicology
Background:
- Assessing chemical toxicity across species is crucial for environmental safety.
- Lipophilicity (lgP) is a key factor influencing chemical bioavailability and toxicity.
- Understanding species-specific toxicity differences aids in regulatory evaluations.
Purpose of the Study:
- To establish empirical relationships between chemical lipophilicity and toxicity ratios in aquatic organisms and mammals.
- To compare the influence of lipophilicity on toxicity between adult fish, fish embryos, and rodents.
- To provide a basis for predicting aquatic toxicity from mammalian toxicity data.
Main Methods:
- Empirical data analysis of 50 chemicals for adult fish and rodents.
- Analysis of 30 chemicals for fish embryos and rodents.
- Calculation of toxicity ratios (LD50/LC50) and correlation with octanol-water partition coefficient (lgP).
- Trend line construction and Pearson's R correlation coefficient for significance.
Main Results:
- Established significant empirical dependences between lgP and toxicity ratios for adult fish and rodent models.
- Revealed similar dependences for fish embryos and rodent models.
- Demonstrated the influence of substance lipophilicity on toxicity for aquatic organisms compared to mammals.
Conclusions:
- Lipophilicity significantly influences the toxicity of chemicals across different species.
- The established dependences can help predict aquatic toxicity based on mammalian data.
- This research contributes to a better understanding of interspecies toxicity variations in chemical risk assessment.
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