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Dependence between LD50 for Rodents and LC50 for Adult Fish and Fish Embryos
K V Zolotarev1, N F Belyaeva2, A N Mikhailov2
1V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia. fireaxe@mail.ru.
Abstract:
We revealed empirical dependences between common logarithm of a ratio of rat oral LD50 to LCa50 for adult fish and lgP for 50 different chemicals; and common logarithm of a ratio of the oral LD50 in rodents to LCe50 for fish embryos and lgP for 30 different chemicals. The dependences were obtained by constructing a trend line between experimental points and calculation of Pearson's R correlation coefficient as a measure of regression significance. These dependences can show the influence of substance lipophilicity on its toxicity for aquatic organisms comparing to mammals.
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