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Coordination of limb development by crosstalk among axial patterning pathways

Irene Delgado1, Miguel Torres1

  • 1Cardiovascular Development Program, Centro Nacional de Investigaciones Cardiovasculares, CNIC, Spain.

Developmental Biology
|March 12, 2017
PubMed
Summary

Vertebrate limb development involves key signaling centers coordinating growth and patterning. Interactions between apical ectodermal ridge (AER), zone of polarizing activity (ZPA), and dorsal/ventral ectoderms ensure proper limb formation.

Keywords:
Apical ectodermal ridgeAxial patterningLimb developmentMorphogenZone of polarizing activity

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