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Using synthetic biology to explore principles of development.

Jamie Davies1

  • 1Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XB, UK jamie.davies@ed.ac.uk.

Development (Cambridge, England)
|March 30, 2017
PubMed
Summary

Synthetic biology offers a novel way to test developmental biology principles. By engineering simple systems, researchers can verify hypotheses about embryogenesis, development, and evolution.

Keywords:
DifferentiationMorphogenesisPattern formationSynthetic biologySynthetic morphologyValidation

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Area of Science:

  • Developmental biology
  • Synthetic biology
  • Evolutionary developmental biology (Evo-devo)

Background:

  • Developmental biology traditionally relies on analytical studies of embryos and experimental perturbations.
  • Distilling and verifying core principles of embryogenesis from experimental data presents a significant challenge.
  • Synthetic biology provides a powerful tool to address these verification challenges.

Purpose of the Study:

  • To review the application of synthetic biology techniques in developmental biology research.
  • To explore how engineered systems can test fundamental principles of embryogenesis.
  • To examine the use of synthetic biology in evolutionary developmental biology studies.

Main Methods:

  • Engineering simple genetic or cellular systems based on developmental biology principles.
  • Utilizing synthetic biology to create model systems for hypothesis testing.
  • Applying these engineered systems to investigate patterning, differentiation, and morphogenesis.

Main Results:

  • Synthetic biology approaches have successfully tested hypotheses related to patterning, differentiation, and morphogenesis.
  • Engineered systems demonstrate the potential to validate theoretical principles of embryogenesis.
  • The methodology is being extended to explore alternative developmental pathways in evo-devo.

Conclusions:

  • Synthetic biology is a valuable approach for verifying principles in developmental biology.
  • This technique allows for the creation of simplified, testable models of complex biological processes.
  • Synthetic biology opens new avenues for understanding evolutionary 'road not taken' scenarios.