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Familial risk for lung cancer
Madiha Kanwal1, Xiao-Ji Ding2, Yi Cao2
1Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, P.R. China; Kunming College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Oncology Letters
|March 31, 2017
Summary
Familial lung cancer, influenced by shared genetics and environment, offers insights into disease origins. Studying these families aids in identifying lung cancer susceptibility genes and improving early detection and prevention.
Area of Science:
- Oncology
- Genetics
- Environmental Health
Background:
- Lung cancer is a major global cause of cancer mortality with a low survival rate.
- While smoking and air pollution are primary causes, genetic factors significantly contribute to lung cancer development.
- A family history of lung cancer elevates risk for both smokers and never-smokers.
Purpose of the Study:
- To review the etiology and molecular biology of lung cancer, focusing on familial lung cancer.
- To systematically discuss characteristics, population-based studies, and genetics of familial lung cancer.
- To highlight familial lung cancer as a model for investigating environmental and genetic interactions and identifying susceptibility genes.
Main Methods:
- Systematic review of existing literature on familial lung cancer.
- Analysis of population-based studies concerning lung cancer aggregation within families.
- Discussion of the genetic underpinnings and molecular biology of familial lung cancer.
Main Results:
- Familial lung cancer arises from a complex interplay of shared environmental exposures and genetic predispositions among family members.
- Studies indicate that familial aggregation is a significant factor in lung cancer risk.
- Familial lung cancer research provides a unique model for understanding gene-environment interactions in lung cancer etiology.
Conclusions:
- Familial lung cancer research is crucial for elucidating lung cancer mechanisms and identifying novel biomarkers for early detection and targeted therapies.
- Understanding familial lung cancer can lead to improved prevention strategies.
- Further investigation into the genetics of familial lung cancer is warranted to identify specific susceptibility genes.