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Updated: Mar 3, 2026

Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry
Published on: September 5, 2014
Atmospheric pressure soft ionization for gas chromatography with dielectric barrier discharge ionization-mass
Mario F Mirabelli1, Jan-Christoph Wolf, Renato Zenobi
1ETH Zurich, Department of Chemistry and Applied Biosciences, CH-8093 Zürich, Switzerland. zenobi@org.chem.ethz.ch.
Abstract:
In this study, a gas chromatography (GC) system was interfaced to a high-resolution Orbitrap mass spectrometer by means of an active capillary plasma ionization source, based on dielectric barrier discharge ionization (DBDI). This allowed highly efficient soft ionization of gas-phase, chromatographically resolved compounds at ambient pressure. Several pesticides and illicit drugs were analyzed, and the limits of detections (LODs) were as low as 30 pg mL-1 for the GC-DBDI-MS coupling (corresponding to 60 fg on-column sensitivity) and 30 fg mL-1 for SPME-GC-DBDI-MS.
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