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Updated: Mar 2, 2026

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Swept-Source OCT Visualization of Macular Hole Closure in Gas-Filled Eyes
Background And Objective:
To assess the utility of swept-source optical coherence tomography (SS-OCT) in visualizing macular hole (MH) closure through gas-filled eyes on postoperative day (POD) 1 using a dual scanning protocol.
Patients And Methods:
We examined 30 consecutive patients with full-thickness MH who underwent standard vitrectomy with SF6 (25%) gas tamponade between July 2015 and April 2016. SS-OCT imaging was performed using horizontal raster and 16-line radial scans with manual delicate focusing to evaluate MH closure status.
Results:
On POD1, optically clear images with visualization of all retinal layers at the fovea were obtained in 80% of eyes, of which 71% achieved complete MH closure. Reasons for unsuccessful imaging included: hyphema (two eyes), dense cataract (two eyes), and gas meniscus interference (two eyes).
Conclusion:
SS-OCT with dual scanning protocol and manual delicate focusing enabled consistent early visualization of foveal architecture for assessment of MH closure through gas-filled eyes. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:392-398.].
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