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Obstructive Sleep Apnea and Chronic Kidney Disease
Josef Yayan1, Kurt Rasche2, Angeliki Vlachou2
1Department of Internal Medicine, Division of Pulmonary, Allergy and Sleep Medicine, HELIOS Clinic Wuppertal, Witten/Herdecke University, Heusnerstrasse 40, 42283, Wuppertal, Germany. josef.yayan@hotmail.com.
Advances in Experimental Medicine and Biology
|June 2, 2017
Summary
Chronic kidney disease (CKD) frequently occurs with obstructive sleep apnea (OSA). This study found CKD develops significantly more often in OSA patients, with increased frequency correlating to OSA severity.
Area of Science:
- Nephrology
- Pulmonology
- Sleep Medicine
Background:
- Obstructive sleep apnea (OSA) and chronic kidney disease (CKD) frequently coexist, but their etiological relationship remains unclear.
- Treating OSA can improve outcomes for patients with CKD, suggesting a significant link between the two conditions.
Purpose of the Study:
- To investigate the relationship between OSA and CKD.
- To determine if there is a mutually exacerbating interaction between the severity of OSA and CKD.
Main Methods:
- Retrospective study of 382 patients from January 2014 to June 2015.
- Diagnosis of OSA confirmed by polysomnography in 95% of patients.
- Assessment of kidney function via blood tests and analysis of comorbidities' influence.
Main Results:
- A high probability of simultaneous OSA and CKD occurrence was observed (Odds Ratio = 3.94, p = 0.005).
- CKD prevalence was higher in patients with OSA (58.9% mild, 74.5% moderate, 71.4% severe) compared to those without OSA (36.8%).
- CKD incidence increased with OSA severity, with hypertension and obesity being common comorbidities.
Conclusions:
- CKD is significantly more prevalent in patients with OSA than in non-OSA individuals.
- The frequency of CKD development escalates with increasing OSA severity.
- These findings highlight the critical association between OSA and CKD, emphasizing the need for screening and management of OSA in kidney disease patients.
Keywords:
Apnea-hypopnea indexChronic kidney insufficiencyComorbiditiesObstructive sleep apneaRenal functionMore Related Videos
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