Related Experiment Video
Updated: Mar 1, 2026
07:34
Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
Published on: December 16, 2022
3.0K
Circadian Rhythms in Diet-Induced Obesity
Atilla Engin1,2
1Faculty of Medicine, Department of General Surgery, Gazi University, Besevler, Ankara, Turkey. dr.aengin@gmail.com.
Advances in Experimental Medicine and Biology
|June 7, 2017
Summary
Disruptions in the body's internal biological clocks, influenced by meal timing and diet, can lead to obesity and metabolic disorders. Maintaining circadian rhythm is crucial for health.
Area of Science:
- Chronobiology
- Metabolic Health
- Obesity Research
Background:
- Circadian timing system coordinates physiological processes with daily cycles.
- Clock genes and adipocytokines exhibit circadian rhythmicity.
- Dysfunction in clock genes is linked to obesity and altered adipokines.
Purpose of the Study:
- To explore the relationship between circadian clock function, feeding patterns, and metabolic disorders.
- To investigate the role of clock genes and adipocytokines in obesity development.
- To understand how desynchronization of central and peripheral clocks impacts metabolic health.
Main Methods:
- Analysis of clock gene expression (e.g., CLOCK, BMAL1) in relation to diet and obesity.
- Examination of adipocytokine rhythmicity and its link to circadian disturbances.
- Investigating the impact of feeding schedules and diet composition on circadian desynchronization.
Main Results:
- Desynchronization between central and peripheral clocks, driven by altered food intake timing and diet, leads to metabolic disorders.
- Disruption of clock genes results in dyslipidemia, insulin resistance, and obesity.
- Shift work and unusual eating times increase the risk of obesity, diabetes, and cardiovascular diseases.
Conclusions:
- Circadian clock disruption, particularly through altered feeding times and diet composition, is a significant factor in the development of obesity and metabolic dysfunction.
- Maintaining circadian alignment is essential for energy homeostasis and preventing metabolic diseases.
- Further research into chrononutrition and circadian interventions may offer therapeutic strategies for obesity and related disorders.
Keywords:
Adenosine monophosphate-activated protein kinase (AMPK)Brain and muscle ARNT-like 1 (BMAL1)Calorie restrictionCircadian rhythmClock genesCryptochrome circadian clock 1 (CRY1)Mammalian target of rapamycin (mTOR)N-methyl-D-aspartate receptors (NMDAR)Nicotinamide phosphoryl-transferaseObesityPeroxisome proliferator-activated receptor (PPAR)ResistinSuprachiasmatic nucleus (SCN)
Related Concept Videos
02:19Circadian Rhythms and Gene Regulation
4.6K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.6K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
430
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
430
02:45Biological Clocks and Seasonal Responses
41.8K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.8K
01:30Regulation of Food Intake
3.0K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
3.0K
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
250
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
250
01:24Metabolic States of the Body: Fasting and Starvation
3.1K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
3.1K