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Mouse Genome Informatics (MGI) Resource: Genetic, Genomic, and Biological Knowledgebase for the Laboratory Mouse.

Janan T Eppig1

  • 1Jackson Laboratory, Bar Harbor, Maine.

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|August 26, 2017
PubMed
Summary
This summary is machine-generated.

The Mouse Genome Informatics (MGI) Resource provides integrated data on mouse genetics and biology to support research. It facilitates disease studies and the development of new therapeutic interventions using advanced computational tools.

Keywords:
databasegeneticsgenomicshuman disease modelinformaticsmodel organismmousephenotypes

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Area of Science:

  • Genetics and Genomics
  • Bioinformatics
  • Mouse Models

Background:

  • The Mouse Genome Informatics (MGI) Resource emerged from the convergence of increasing genetic and biological data with advancements in computer technology, including the World Wide Web, in the late 1980s.
  • MGI plays a crucial role in supporting basic, translational, and computational research by offering integrated, high-quality data on the laboratory mouse.

Purpose of the Study:

  • To review the historical development and strategic role of the Mouse Genome Informatics (MGI) Resource.
  • To highlight MGI's function in facilitating biomedical research, disease investigation, and the development of therapeutic interventions.
  • To describe specific MGI contributions, focusing on large-scale mutagenesis and phenotyping projects and data accessibility.

Main Methods:

  • Data integration and curation of genetic, genomic, and biological information for the laboratory mouse.
  • Development and maintenance of a gold-standard resource reflecting current scientific knowledge.
  • Creation of advanced tools for data searching, analysis, and hypothesis testing.
  • Collaboration with the scientific community to address research data requirements.

Main Results:

  • MGI provides a comprehensive, semantically integrated resource for mouse genetics and biology.
  • The resource supports hypothesis testing and the development of new disease models and therapeutic strategies.
  • Specific focus on community-wide large-scale mutagenesis and phenotyping projects demonstrates MGI's utility.

Conclusions:

  • The Mouse Genome Informatics (MGI) Resource is an essential, evolving platform for mouse research.
  • MGI's integrated data and advanced tools empower scientific discovery in genetics, genomics, and disease biology.
  • Accessing and utilizing MGI data, particularly from mutagenesis and phenotyping initiatives, is crucial for advancing biomedical research.