Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spermatogenesis01:41

Spermatogenesis

123.9K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
123.9K
Spermatogenesis01:22

Spermatogenesis

10.0K
Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
10.0K
Sperm Transport01:15

Sperm Transport

4.0K
The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
4.0K
The Ratio of X Chromosome to Autosomes02:45

The Ratio of X Chromosome to Autosomes

9.9K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
9.9K
Meiosis II01:57

Meiosis II

209.3K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
209.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Centenarian SIRT6 variants elevate SIRT6 protein and enhance cellular senescence resistance.

Research square·2026
Same author

Microgels prepared by microfluidics from structural design to practical applications: Development and challenge.

Advances in colloid and interface science·2026
Same author

Correction: <i>Mycobacterium tuberculosis</i> MarR family transcription factor Rv0737 regulates bacterial growth and lipid synthesis by targeting the sigL-rslA operon.

Frontiers in microbiology·2026
Same author

Unraveling Glycation-Induced Structure-Function Nexus in Food Proteins: From Analytical Innovations to AI-Assisted Design.

Comprehensive reviews in food science and food safety·2026
Same author

ECHOS enables spatial epigenome profiling at subcellular resolution.

bioRxiv : the preprint server for biology·2026
Same author

Route-Dependent Proteomic Landscape in Mouse Models of Carbon Tetrachloride-Induced Hepatic Fibrosis.

Journal of proteome research·2026
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Feb 23, 2026

Cytological Analysis of Spermatogenesis: Live and Fixed Preparations of Drosophila Testes
10:30

Cytological Analysis of Spermatogenesis: Live and Fixed Preparations of Drosophila Testes

Published on: January 20, 2014

30.0K

Drebrin and Spermatogenesis.

Haiqi Chen1, Michelle W M Li1, C Yan Cheng2

  • 1The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Ave., New York, NY, 10065, USA.

Advances in Experimental Medicine and Biology
|September 3, 2017
PubMed
Summary
This summary is machine-generated.

Drebrin E protein plays a crucial role in spermatogenesis by organizing actin filaments at specialized junctions in the testis. This protein is vital for germ cell transport during the epithelial cycle, supporting sperm production.

Keywords:
Actin microfilament bundlesArp2/3 complexBlood-testis barrierBranched actin polymerizationDrebrinEctoplasmic specializationF-actinSeminiferous epithelial cycleSpermatogenesisTestis

More Related Videos

Ex vivo Culture of Drosophila Pupal Testis and Single Male Germ-line Cysts: Dissection, Imaging, and Pharmacological Treatment
08:35

Ex vivo Culture of Drosophila Pupal Testis and Single Male Germ-line Cysts: Dissection, Imaging, and Pharmacological Treatment

Published on: September 11, 2014

18.0K
Easy and Reproducible Low-Density Primary Culture using Frozen Stock of Embryonic Hippocampal Neurons
04:26

Easy and Reproducible Low-Density Primary Culture using Frozen Stock of Embryonic Hippocampal Neurons

Published on: January 27, 2023

2.9K

Related Experiment Videos

Last Updated: Feb 23, 2026

Cytological Analysis of Spermatogenesis: Live and Fixed Preparations of Drosophila Testes
10:30

Cytological Analysis of Spermatogenesis: Live and Fixed Preparations of Drosophila Testes

Published on: January 20, 2014

30.0K
Ex vivo Culture of Drosophila Pupal Testis and Single Male Germ-line Cysts: Dissection, Imaging, and Pharmacological Treatment
08:35

Ex vivo Culture of Drosophila Pupal Testis and Single Male Germ-line Cysts: Dissection, Imaging, and Pharmacological Treatment

Published on: September 11, 2014

18.0K
Easy and Reproducible Low-Density Primary Culture using Frozen Stock of Embryonic Hippocampal Neurons
04:26

Easy and Reproducible Low-Density Primary Culture using Frozen Stock of Embryonic Hippocampal Neurons

Published on: January 27, 2023

2.9K

Area of Science:

  • Cell Biology
  • Reproductive Biology
  • Biochemistry

Background:

  • Drebrins are actin-binding proteins regulating cellular functions.
  • Drebrin E is implicated in testis function during spermatogenesis.
  • Actin microfilament organization is critical at ectoplasmic specializations (ES) in the seminiferous epithelium.

Purpose of the Study:

  • To evaluate the role of drebrin E in actin organization at the ectoplasmic specialization (ES) during spermatogenesis.
  • To investigate drebrin's recruitment of actin-related protein 3 (Arp3).
  • To propose a model for drebrin's involvement in germ cell transport.

Main Methods:

  • Literature review and data evaluation.
  • Analysis of drebrin's interaction with Arp3.
  • Hypothetical modeling of cellular processes.

Main Results:

  • Drebrin E facilitates actin microfilament organization at apical and basal ES.
  • Drebrin E recruits Arp3, influencing actin polymerization at ES.
  • The study provides a hypothetical model for drebrin's role in germ cell transport.

Conclusions:

  • Drebrin E is essential for maintaining the structural integrity of the seminiferous epithelium via actin organization.
  • Understanding drebrin's function offers insights into spermatogenesis and potential therapeutic targets.
  • The proposed model highlights drebrin's significance in germ cell movement during the epithelial cycle.